Ma, Jinbiao, Professor

E-mail: majb@fudan.edu.cn

From 1992 to 1997, Jinbiao Ma studied chemistry at Fudan University and received his B.A. in Chemistry in 1997. He obtained his Ph.D. in Organic Chemistry in 2002.

From 2002 to 2007, he was a post-doctoral fellow, research associate and senior research scientist in Sloan-Kettering Cancer Center with Prof. Dinshaw Patel. In 2007, he became a tenure-track assistant professor at University of Alabama at Birmingham and continued his research on structural study of biogenesis and metabolism of small noncoding RNAs. In 2011, he moved back to Fudan University as Professor in the School of Life Sciences, and expanded his research areas to studying the structures of protein machinery involved in nucleic acid modification and editing as well as epigenetics. Since 2017, he is the associate director of State Key Laboratory of Genetic Engineering.

Research Interests

Dr. Jinbiao Ma mainly focuses on three dimensional structural basis and molecular mechanism of protein-protein and protein-nucleic acid interactions in RNA modification and epigenetics, using protein X-ray crystallography as major methods in combination with various biochemistry and biophysics methods.

Awards

• 2008, The V Scholar Award, NCI-UAB Junior Faculty Development Grants (JFDG).
• 2010, Shanghai Oriental Scholar
• 2011, 1000 Young Talents Plan, Shu Guang Project
• 2012, Shanghai Pujiang Program

Selected publications

1. Chen J, Liu L, You C, Gu J, Ruan W, Zhang L, Gan J, Cao C, Huang Y, Chen X, Ma J. (2018) Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun. 9(1):3585.
2. Wu B, Su S, Patil D, Liu H, Gan J, Jaffrey SR, Ma J. (2018) Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun. 9(1):420.
3. Zhu Y, Rong L, Luo Q, Wang B, Wang Y, Zhang Ch, Feng H, Zheng L, Shen W, Ma J *, Dong A *. (2017) The histone chaperone NRP1 interacts with WEREWOLF to activate GLABRA2 in Arabidopsis root hair development, Plant Cell. 29(2): 260-267.
4. Liu H, Yu X, Chen Y, Zhang J, Wu B, Zheng L, Haruehanroengra P, Wang R, Li S, Lin J, Li J, Sheng J, Huang Z, Ma J*, Gan J*. (2017) Crystal structural of RNA-cleaving DNAzyme, Nature Communication .8:2006.
5. Yu X, Li X, Zheng L, Ma J *, Gan J *. (2017) Structural and functional studies of a noncanonical Dicer from Entamoeba histolytica, Scientific Reports. 7: 44832.
6. Chen Y，Zhang J，Liu H，Gao Y，Li X，Zheng L，Cui R，Yao Q，Rong L，Li J，Huang Zh，Ma J *，Gan J *. (2017) Unique 5'-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X.，PLoS Biology. 15(2):e1002599.
7. Liu H，Cai Ch，Haruehanroengra P，Yao Q，Chen Y，Yang Ch，Luo Q，Wu B，Li J，Ma J *，Sheng J *，Gan J *. (2016) Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex.，Nucleic Acids Research. 45(5):2910~2918.
8. Zhang J，Liu H，Yao Q, Yu X，Chen Y，Cui R，Zheng L，Wu B，Zuo J，Huang Zh，Ma J *，Gan J * .(2016) Structural basis for single-stranded RNA recognition and cleavage by C3PO，Nucleic Acids Research. 44(19):9494~9504.
9. Du H，Zhao Y，He J，Zhang Y，Xi H，Liu M，Ma J *, Wu L *.（2016）YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nature Communications. 7:12626.
10. Huang Y，Ji L，Huang Q，Vassylyev D，Chen X，Ma J. (2009) Structural insights into mechanisms of the small RNA methyltransferase HEN1，Nature.461(7265):823~U